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Stimulants 

Stimulants speed up the messages going to and from your brain. Caffeine,

nicotine, amphetamines (like speed or ice),     ecstasy and cocaine are

stimulants. Using stimulants:

     *  puts a strain on your heart

     *  increases your body temperature

     *  stops you feeling hungry

     *  and can make you paranoid, anxious or psychotic

 

Mixing stimulants with each other or with depressants puts extra strain on your heart and can cause major health problems.

 

Hallucinogens

Hallucinogens change your perception of reality. LSD, magic mushrooms, ecstasy,

mescaline, and high doses of cannabis are all hallucinogenic drugs. People who take 

hallucinogens often have 'trips' which is when they hear and see things that aren’t

really there. How your 'trip' goes depends on your mood, state of mind and setting.

You can't predict whether it will      *  be good or bad, or how strong it will be.

Hallucinogens can: 

     *  make you panicked, anxious or paranoid

     *  make you take risks you wouldn't normally take

     *  make you lose touch with reality (psychosis ).

 

Mixing drugs can be dangerous

– and that includes alcohol. It can be dangerous because it can really mess up the chemistry in

your body, and cause serious or life threatening damage to your health. It can also be dangerous

because it could make you do dangerous things.

 

 

Illegal drugs

Drugs are made illegal when they pose serious risk to people’s health. Taking

illegal drugs can be dangerous because, apart from the negative health impacts

of the drug itself, there is no quality control over what you’re taking. You've

got no way of knowing how strong or weak the drug is, or whether there are

other dangerous substances mixed into it which could cause serious health

issues. It’s possible that you might take way too much, or even different stuff

to what you were after. If you get caught with illegal drugs by the police you

can be arrested and charged.

 

 

STP (DOM)

 

STP is a synthetic hallucinogen whose chemical name is 2, 5-Dimethoxy-4-methylamphetamine – often referred to as DOM (STP is the drug’s street name and stands for Serenity, Tranquillity and Peace). Like more well known hallucinogens, such as LSD and Magic Mushrooms, STP induces an altered state of mind in users known as a ‘trip’.

 

The chemical is entirely man-made and was first synthesised by renowned ‘counterculture’ chemist and pharmacologist, Alexander Shulgin. Shulgin is often referred to as the ‘Godfather of Ecstasy’ for his scientific and often personal experimentation with MDMA. He also actively worked to create new chemicals which could be used for psychedelic experiences in conjunction with legitimate work for the DOW Chemical company, and STP (DOM) was one such result.

 

Shulgin first synthesized the drug in 1964, partially basing his work around the chemical structure of Mescaline, a psychedelic substance derived from the Peyote cactus. He described the synthesis of the drug and the subjective results of testing it on himself, along with many other chemicals, in the infamous book PIHKAL (‘Phenethylamines I Have Known and Loved’). His documented experiences with the drug ranging from euphoria and increased sensitivity to colours, to vivid hallucinations and frightening delusions.

 

Shulgin experimented with doses between 1-12mg (the latter being judged by him as far too high). However, in 1967 in San Francisco, during the height of the ‘summer of love’ DOM tablets bearing the name STP emerged on the street, and these contained 20mg of active ingredient. This high dose, combined with delays in the drug taking effect (and extra doses being taken) led to a large number of non-fatal overdoses in which the users had terrifying experiences which left them panicked and in search of emergency medical attention.

 

                                                               

 

 

 

 

 

 

 

 

 

 

OTHER TYPES

STP stands for Serenity, Tranquillity and Peace, and is the street name of the synthetic drug DOM (2,5 Dimethoxy-4-Methylamphetamine).

 

 

 

 

 

 

 

 

 

Alternative explanations of the acronym STP include Stop the Police and Super Terrific Psychedelic. Alexander Shulgin himself relates that police during the ‘hippie era’ often referred to it as Too Stupid to Puke.  The letters STP are also used to denote a popular brand of fuel oil additive in the US, leading some to believe that the two were related, but this was never the case.

 

MAJOR EFFECTS

As a hallucinogenic drug, STP induces a variety of psychological and physiological effects which constitute a ‘trip’. The exact effects can vary widely according to the strength of dose taken and the individual, but commonly include visual and auditory hallucinations, heightened perception of colours, textures etc, feelings of euphoria and other psychedelic effects in common with drugs like LSD and Mescaline.

 

One of the major risks of taking STP/ DOM is that the user will take too much. The drug is relatively rare, and people who are more familiar with LSD and other hallucinogenic drugs may unwittingly take an amount which is many times an active dose. Because the drug’s effects have a slow onset period of 1-2 hours, it is also not uncommon for an individual to take an extra dose in the belief that the drug is not ‘working’ during this period. There have been no reports of fatal overdoses, but those who have an overdose of STP commonly become panicked, increasingly anxious and in some cases temporarily psychotic. Some scientific literature suggests that overdose may also result in convulsions and toxic reactions, leading to death.

 

As with other psychedelics, individuals may also experience a ‘bad trip’ while on the drug, encompassing negative and unpleasant hallucinations, intense anxiety, delusions and paranoia. They may also believe that they are going crazy or about to die.

 

While under the influence of the drug, the individual will be less able to respond to their surroundings in an appropriate way. They can be highly prone to accidental injury or misadventure, and users who are not familiar with hallucinogenic drugs may take dangerous actions based on drug-induced delusions and hallucinations.

 

 

PRODUCTION COUNTRIES

STP/ DOM is an entirely synthetic drug created in a laboratory, and was synthesized for the first time by Alexander Shulgin in 1964, while working for DOW Chemical. Shulgin created it based around existing psychedelic drugs known in nature, such as Mescaline, with the intention of creating a drug for psychedelic use and the possible treatment of mental illness. However, as the Sixties progressed, legitimate scientific experimentation with hallucinogens fell out favour, and the drug was never released or manufactured in mainstream channels.

 

For the first few years that the drug was known about there were no laws governing its manufacture or possession, so it was produced by knowledgeable chemists in labs such as Shulgin’s. In the US, STP was made illegal to distribute in 1968, but remained legal for personal use. In 1973 it was made illegal altogether and designated as a Schedule I drug.

 

This drove production underground, and little data is available as to specific locations where manufacture of STP is currently prevalent. It is however likely that the drug is produced in illegal drug laboratories in North America, Europe and elsewhere in the developed world. It may be produced by organised criminals alongside other synthetic drugs such as MDMA (Ecstasy) and so-called ‘designer drugs’. It is also possible that it may be manufactured in smaller quantities by independent chemists working from home labs.

 

Once manufactured, supplies of DOM are likely to be sold to mid-level dealers, smuggled across borders if necessary, and then sold to street dealers, as is the case with most synthetic illicit drugs. The drug is relatively rare but may be bought on the street as an off-white powder, or pressed into tablet form.

 

FACTS AND STATS

 

FACTS

     1.   STP is the street name for the synthetic hallucinogenic drug DOM (2, 5-Dimethoxy-4-methylamphetamine)

     2.   STP stands for Serenity, Tranquillity and Peace

     3.   The effects of the drug are similar to more well known psychedelic drugs such as Mescaline and LSD.

     4.   Major effects include hallucinations, altered perceptions, cognitive distortions and delusions.

     5.   Users may experience a ‘bad trip’ over which they have little control. Before taking the drug there is no way of                  telling whether a bad trip will ensue.

     6.   Anxiety and psychosis are among the negative effects experienced by users.

     7.   It was first synthesised by chemist/ pharmacologist Alexander Shulgin in 1964.

     8.   In the US it is a Schedule I illegal drug.

     9.   In Australia it is Schedule II under the Drugs Misuse Regulations 1987.

     10. In the UK it was made a Class A drug in the same category as Heroin and Cocaine in 1971.

     11.  DOM/ STP is listed in the UN Convention on Psychotropic Drugs as a Schedule I substance.

     12.  The drug first came to prominence following a spate of highly publicised overdoses in San Francisco during the              ‘Summer of Love’ in the 1960s. These were in part due to excessively high doses and ignorance of the true content             of the drugs, which were distributed freely.

     13.  The drug is relatively rare in most countries, and is produced in illegal clandestine laboratories.

     14.  Frequent use of STP and other psychedelic drugs can lead to temporary increases in tolerance, meaning that                    higher doses need to be taken to achieve the same effects.

     15.  STP is not thought to be chemically addictive, but it can be psychologically addictive, and may be used in a ‘poly-            drug’ habit with other hallucinogens and illicit drugs.

 

STATS

     1.   The effects of the drug can take 1-2 hours to manifest themselves.

     2.   These effects can last up to 24 hours, and are often felt for at least 16 hours.

     3.   The ‘active dose’ of STP/ DOM is between 1-5mg

     4.   When the drug was distributed in San Francisco in 1967 it was in tablets of 20mg in strength. 5,000 doses were                  said to be handed out to crowds at a free event there. It has been estimated that some individuals took doses in

           excess of 30mg.

     5.   In the UK it is a class A drug. Possession of STP can lead to up to seven years in prison and an unlimited fine.                    Supplying the drug, even to friends, can result in a life sentence and an unlimited fine.

     6.   In the US, trafficking of the drug is punishable by up to 20 years and a fine of $1million. Second offences can                      result in 30 years in prison and a $2million fine.

     7.   During early clinical studies, a number of volunteers were given a dose of 6mg each day for three days. By the                  third day, the volunteers showed significantly diminished responses to the doses, illustrating tolerance to the                  drug.

 

 

ADDICTION SIGNS

Like most hallucinogenic drugs, there is no evidence to suggest that STP/DOM is physically addictive in the same way that other Class A drugs such as Heroin and Cocaine are. However it can result in a profound psychological addiction which has far-reaching consequences across all aspects of an individual’s life and mental wellbeing.

 

In many cases, addictive behaviour surrounding STP use will most likely be a more generalised psychological addiction to a broad spectrum of psychedelic drugs, which may also include LSD, Magic Mushrooms, Mescaline and a range of other synthetic ‘designer’ hallucinogens.

 

While under the influence of STP the individual may appear to be ‘not with it’ and they may respond to external stimuli which are not really there. They may seem intrigued by seemingly mundane and everyday objects, and spend some time examining colours, textures and other sensations. They may also appear delusional or even anxious and paranoid.

Frequent users may appear to be increasingly losing touch with reality. They may show little interest in things that previously interested them, and fail to attend to important matters which require their attention. In some cases they might act out delusional fantasies, or display other signs of mental imbalance.

 

Small tablets may be found in their belongings, though discerning these as STP specifically may be difficult. The drug may also be found in the form of a whitish powder in a bag or wrapped up in clingfilm. Other signs of more generalised psychedelic drug abuse may be ‘blotters’ of acid with colourful pictures on them, vials of liquid or dried mushrooms.

 

TREATMENTS

Because STP is not known to create a physical chemical dependency, there are generally few side effects from ceasing use, and detox can be done safely without the need for any substitute chemicals or special treatment. However, in some cases, the psychological aftermath of long term STP use may be more difficult to deal with.

 

Because STP is a relatively rare drug and is more often than not just one part of an illicit psychedelic drug habit, there are no specific treatment programmes for dealing with it. Instead a more holistic approach may be taken that treats the psychological addiction to psychedelic drugs in general, and deals with the consequences of their abuse.

 

Because there are no substantial physical withdrawals from STP, it is not necessary for the individual to enter rehabilitation centre for detox and treatment. In some cases however, where profound mental disturbance and impairment has occurred, this may be advisable or desirable.

Once the individual has admitted that they have a problem with drug use, the first step is to cease this use of STP and other illicit chemicals. Except in cases where opiates or other chemically addictive drugs are also involved, this can generally be done straight away, with no need to taper off dosage or use.

Despite the lack of physical dependency, the psychological relationship that the user has with STP and other hallucinogens can be substantial. Particularly in the early stages of treatment, they may have intense mental cravings to ‘take a trip’ by ingesting STP or another substance.

Treatment will generally focus on the psychological nature of the drug habit. Talking therapies and counselling sessions may seek to root out the primary reasons for the individual’s drug use, and to identify the triggers which compel them to ‘escape’ from everyday reality. Behaviour modification therapies such as CBT (Cognitive Behavioural Therapy) may then help them to deal with these triggers which may cause relapse, and encourage them to develop new healthy alternative behaviours.

 

Support groups with individuals who are recovering from similar addictions can also help by fostering a sense of community, and by providing an additional avenue for much-needed emotional support during the recovery process. Some individuals who have been abusing psychedelic drugs in large quantities over long periods of time may require more specialist psychiatric help to enable them to return to normal functioning. They may have difficulties adjusting to both their experiences while on the drugs, and the relative normality of a drug-free life. It is not known if ‘flashbacks’ ( a sudden mental reoccurrence of a ‘trip’, months or years after use) occur due to STP use, but these have been linked to use of other psychedelic drugs such as LSD, and may be disturbing for the patient.

 

In addition to this, people who already have latent mental illnesses and personality disorders may have these triggered by psychedelic drug use. In these instances, diagnosis and appropriate treatment by a mental health professional is necessary.

 

REFERENCES

 

      *  www.drugs-forum.com/forum/showthread.php?t=898

      *  www.erowid.org/chemicals/dom/dom_timeline.php

      *  www.erowid.org/library/books_online/pihkal/pihkal068.shtml

      *  www.enotes.com/dom-reference/dom

      *  addaction.nemisys2.uk.com/page.asp?section=215&sectionTitle=D#dom

      *  www.sunshinecoasthealthcentre.ca/hallucinogens.html

      *  oldwp.summitmalibu.com/malibu-drug-alcohol-dual-diagnosis-rehab/addiction-abuse/drug-addiction-and-                       abuse/dom-stp-abuse-and-addiction

      *  www.legislation.qld.gov.au/LEGISLTN/CURRENT/D/DrugsMisuseR87.pdf

      *  www.justice.gov/dea/agency/penalties.htm

      *  unosek.org/unodc/en/data-and-analysis/bulletin/bulletin_1970-01-01_1_page006.html

      *  axon.psyc.memphis.edu/~charlesblaha/3507/Opiates/Lecture%20-%20Hallucinogens%20-%203507.pdf

      *  www.drugscope.org.uk/resources/faqs/faqpages/how-many-people-use-drugs

 

 

Suffer The Little Children

WHAT  ABOUT  DRUGS

Age-related gray matter loss in healthy volunteers (right) versus cocaine-addicted volunteers of the same age (left).

Cocaine is a strong central nervous system stimulant that increases levels of the neurotransmitter dopamine in brain circuits regulating pleasure and movement.

 

Normally, dopamine is released by neurons in these circuits in response to potential rewards (like the smell of good food) and then recycled back into the cell that released it, thus shutting off the signal between neurons. Cocaine prevents the dopamine from being recycled, causing excessive amounts to build up in the synapse, or junction between neurons. This amplifies the dopamine signal and ultimately disrupts normal brain communication. It is this flood of dopamine that causes cocaine’s characteristic high.

 

With repeated use, cocaine can cause long-term changes in the brain’s reward 

 

AMPHETAMINS

Amphetamine (pronunciation: i/æmˈfɛtəmiːn/; contracted from alpha‑methylphenethy-

lamine) is a potent central nervous system (CNS) stimulant of the phenethylamine class that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and nar-colepsy. Amphetamine was discovered in 1887 and exists as two enantiomers: levoam phetamine and dextroamphetamine.  Amphetamine properly refers to a specificchemical, the racemic free base, which is equal parts of the two enantiomers, levoamphetamine and dextroamphetamine, in their pure amine forms. However, the term is frequently used informally to refer to any  combination of the enantiomers, or to either of them alone. 

Historically, it has been used to treat nasal congestion, depression, and obesity. Amphetamine is also used as a performance andcognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a prescription medication in many countries, and unauthorized possession and distribution of amphetamine is often tightly controlled due to the significant health risks associated with uncontrolled or heavy use.

 

The first pharmaceutical amphetamine was Benzedrine, a brand of inhalers used to treat a variety of conditions. Currently, pharmaceutical amphetamine is typically prescribed as Adderall, dextroamphetamine, or the inactive prodrug lisdexamfetamine. Amphetamine, through activation of a trace amine receptor, increases biogenic amine and excitatory neurotransmitter activity in the brain, with its most pronounced effects targeting the catecholamine neurotransmitters norepinephrine and dopamine. At therapeutic doses, this causes emotional and cognitive effects such as euphoria, change in libido, increased wakefulness, and improved cognitive control. It induces physical effects such as decreased reaction time, fatigue resistance, and increased muscle strength.

 

Much larger doses of amphetamine are likely to impair cognitive function and induce rapid muscle breakdown. Substance dependence(addiction) is a serious risk of amphetamine abuse, but only rarely arises from medical use. Very high doses can result in psychosis (e.g., delusions and paranoia) which rarely occurs at therapeutic doses even during long-term use. Recreational doses are generally much larger than prescribed therapeutic doses, and carry a far greater risk of serious side effects.

 

Amphetamine is also the parent compound of its own structural class, the substituted amphetamines, which includes prominent substances such as bupropion, cathinone, MDMA (ecstasy), and methamphetamine. Unlike methamphetamine, amphetamine's salts lack sufficient volatilityto be smoked. As a member of the phenethylamine class, amphetamine is also chemically related to the naturally occurring trace amine neurotransmitters, specifically phenethylamine and N-methylphenethylamine, both of which are produced within the human body.

COCAINE (Erythroxylon Coca)

Cocaine is a powerfully addictive stimulant drug made from the leaves of the coca plant native to South America. It produces short-term euphoria, energy, and talkativeness in addition to potentially dangerous physical effects like raising heart rate and blood pressure.

How Is Cocaine Used?

The powdered form of cocaine is either inhaled through the nose (snorted), where it is absorbed through the nasal tissue, or dissolved in water and injected into the bloodstream.

 

Crack is a form of cocaine that has been processed to make a rock crystal (also called “free-base cocaine”) that can be smoked. The crystal is heated to produce vapors that are absorbed into the blood-stream through the lungs. (The term “crack” refers to the crackling sound produced by the rock as it is heated.)

The intensity and duration of cocaine’s pleasurable effects depend on the way it is adminis-tered. Injecting or smoking cocaine delivers the drug rapidly into the bloodstream and brain, producing a quicker and stronger but shorter-lasting high than snorting. The high from snorting cocaine may last 15 to 30 minutes; the high from smoking may last 5 to 10 minutes.

 

In order to sustain their high, people who use cocaine often use the drug in a binge pattern—taking the drug repeatedly within a relatively short period of time, at increasingly higher doses. This practice can easily lead to addiction, a chronic relapsing disease caused by changes in the brain and characterized by uncontrollable drug-seeking no matter the consequences.

How Does Cocaine Affect the Brain?

system as well as other brain systems, which may lead to addiction. With repeated use, tolerance to cocaine also often develops; many cocaine abusers report that they seek but fail to achieve as much pleasure as they did from their first exposure. Some users will increase their dose in an attempt to intensify and prolong their high, but this can also increase the risk of adverse psychological or physiological effects.

 

Cocaine may speed up the aging of the brain, according to new research that finds that people who are addicted to the drug lose twice the brain volume each year as non-drug users.

 

As the brain ages, it inevitably loses gray matter, the part of brain tissuemade up of neuron cell bodies. Loss of gray matter is linked with many of the signs of old age, including memory problems and other declining cognitive abilities, said study researcher Karen Ersche, a neuroscientist at the University of Cambridge.

Middle-age cocaine-dependent people show many of the signs of aging,including cognitive decline, Ersche told LiveScience. To look at the under-lying cause, she and her colleagues used magnetic resonance imaging (MRI) to measure gray matter volume in 60 adults with cocaine dependence and 60 adults without substance-use troubles who were similar to the cocaine-

abusing volunteers in age, gender and verbal IQ.

 

They found that cocaine-dependent adults showed twice the gray matter loss as their healthy counterparts: 3.08 milliliters per year in cocaine users versus 1.69 milliliters per year in people without substance abuse. [Best Games to Keep Your Brain Sharp

The results held true even after those cocaine users who were also alcohol-addicted (16 individuals) were removed from the analysis, pointing to the drug as a cause. Although it's not possible to experiment on the human brain, animal studies suggest that cocaine-related brain atrophy may be related to oxidative stress, Ersche said. Oxidative stress is caused by the production of unstable molecules called reactive oxygen species; when the body can't remove these molecules or repair the damage they cause, disease can result.

 

"We have a growing number of older people seeking treatment for drug problems," Ersche said. "The Baby Boomer generation is a generation that has used more drugs than any generation before them, so they actually may suffer from an accelerated aging process, and we need to take this into account when we provide treatment."

 

About 21 million people use cocaine worldwide, a number that includes one-time users; In the United States, about 1 percent of the population older than 12 currently uses the drug, according to the Office of National Drug Control Policy. Nonetheless, older drug users tend to be invisible in public discourse and public policy, Ersche said. Treatment and prevention programs are skewed toward youth, she said, and little funding is available to study older adults. (The current study was funded by pharmaceutical company GlaxoSmithKline, and Ersche is supported by the Medical Research Council.)

What Are the Other Health Effects of Cocaine?

 

Cocaine affects the body in a variety of ways. It constricts blood vessels, dilates pupils, and increases body temperature, heart rate, and blood pressure. It can also cause headaches and gastrointestinal complications such as abdominal pain and nausea. Because cocaine tends to decrease appetite, chronic users can become malnourished as well.

Most seriously, people who use cocaine can suffer heart attacks or strokes, which may cause sudden death. Cocaine-related deaths are often a result of the heart stopping (cardiac arrest) followed by an arrest of breathing.

 

People who use cocaine also put themselves at risk for contracting HIV, even if they do not share needles or other drug paraphernalia. This is because cocaine intoxication impared judgment and can lead to risky sexual behavior.

 

Some effects of cocaine depend on the method of taking it. Regular snorting of cocaine, for example, can lead to loss of the sense of smell, nosebleeds, problems with swallowing, hoarseness, and a chronically runny nose. Ingesting cocaine by the mouth can cause severe bowel gangrene as a result of reduced blood flow.

Injecting cocaine can bring about severe allergic reactions and increased risk for contracting HIV, hepatitis C, and other blood-borne diseases.

 

Binge-patterned cocaine use may lead to irritability, restlessness, and anxiety. Cocaine abusers can also experience severe paranoia—a temporary state of full-blown paranoid psychosis—in which they lose touch with reality and experience auditory hallucinations.

 

Cocaine is more dangerous when combined with other drugs or alcohol (poly-drug use). For example, the combination of cocaine and heroin (known as a “speedball”), carries a particularly high risk of fatal overdose

Depressants

Depressants slow down messages to and from your brain. Alcohol, opiates (like heroin and morphine), cannabis, sedatives (like valium), and some glues, petrols and other solvents are all depressants. If you take different types of depressants at the same time you're more likely to overdose (OD), so if you're using depressant drugs, the safest way to do so is to stick to one type of drug.

Large amounts of depressants can;

SIGNS and SYMPTOMS:

The user will appear to have an euphoric feeling and be energetic.  Pupils are dialated and fixed.  Tremors may occur.  The euphoric sensations are short lived and quickly replaced by feelings of anxiety and the pression, generally accompanied by hallucinations and paranoid delusions.  The user may indicate a feeling of superiority.  

 

Slang terms: "Coke", "Snow", "Happy birds", "Cecil", "Stardust", "Bernice Gold Dust".

     * make you pass out

     * stop breathing

     * make you feel sick and vomit

STP was made illegal in the US in 1973, and many governments around the world followed suit.  The effects of STP are similar to LSD and trigger a range of psychedelic effects  when taken. These include hallucinations, euphoria, distorted perceptions and cognitions, and delusional states of mind.  There is little data available on current usage trends of STP/ DOM, but it is thought to be made available on the street by illegal laboratories and small-scale ‘home chemists’.

The name STP is thought to have emerged during the drug’s first major appearance in 1960’s San Francisco. At this time few people realised that the drug referred to as STP was in fact DOM, and this led to further problems in treating over-doses. Those who were overdosing on STP were given Thor-azine in the emergency room – a standard treatment for LSD overdoses, but one which simply enhanced the potent effects of DOM.

There are many illegal drugs,

COCAINE is one of the worst! 

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